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Coronavirus (Covid-19)

Covid-19 vaccine may involve 2 doses

Maya Taylor

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PHOTO: Dimitri Houtteman on Unsplash

Health experts in the US say that when a viable coronavirus vaccine is found, it may need to be administered in 2 separate doses, in order to be effective. This throws up all sorts of logistical problems, with Kelly Moore, a health policy professor at Vanderbilt University, expressing concern over procurement issues and the difficulty in getting people to show up not once, but twice.

“There’s no question that this is going to be the most complicated, largest vaccination programme in human history, and that’s going to take a level of effort, a level of sophistication, that we’ve never tried before.”

Meanwhile, the US Food and Drug Administration has not ruled out the possibility of giving emergency approval to a vaccine candidate before it has finished the necessary safety and effectiveness trials. China and Russia have already done this, a move that has been criticised by health officials around the world, including the US.

Stephen Hahn, Commissioner of Food and Drugs Administration, says any request for emergency approval has to be made by the vaccine developer. He insists he is not bowing to pressure from US President Donald Trump, who has previously said the US may have a vaccine ahead of November’s presidential election.

“If they do that before the end of Phase Three, which involves large-scale human testing, we may find that appropriate. We may find that inappropriate, we will make a determination. This is going to be a science, medicine, data decision. This is not going to be a political decision.”

The announcement comes as Phase 3 trials continue on vaccine candidates from 3 companies. AstraZeneca has teamed up with researchers at Oxford University, Moderna is working with the US National Institutes of Health, while Pfizer is partnering with BioNTech. Half of those taking part in the trials receive the vaccine candidate, while the other half are given a placebo. It normally takes months before results can be properly evaluated.

Meanwhile, Nada Sanders, a professor of supply chain management at Northeastern University, is concerned about logistics, should 2 separate doses of the vaccine be required.

“We’re looking at double shots. That’s twice the amount. Doubling is a huge supply chain issue. You have to double everything in the supply chain. The syringes, can they double up? Can the vials double up? Can the stoppers double up? Can the needles double up? Everybody has to double up, and then they all have to get it in time at the various entities along the supply chain.”

She points to the PPE crisis at the start of the outbreak, and the shortage of testing kits.

“We’re talking about such exactness, and we couldn’t get PPE right, so I’m concerned. There are many weaknesses across this supply chain, many. If we don’t address this now, the probability of failure is very high.”

In addition, Nelson Michael, from the Centre for Infectious Diseases Research at Walter Reed Army Institute of Research, says getting people to come twice to be vaccinated may prove a big ask. While 40% of Americans say they will refuse to have any Covid-19 vaccine, Michael says even getting those not oppposed to vaccination to come twice may prove a challenge. They may have to take time off work twice, wait in line twice, and put up with side-effects twice.

“These are the sorts of things that I think we need to think about, to make sure that we can incentivise people to come back, to make it as easy as possible for them to adhere to a two shot regimen.”

Meanwhile, Eric Topol from the Scripps Research Translational Institute, has taken to Twitter to hit out at the idea that a vaccine could be approved without completing clinical trials, accusing Hahn of capitulating to Trump’s demands.

“It is f*cking outrageous to expedite any approval of a #SARSCoV2 vaccine, irrespective of @SteveFDA’s subservience to Trump. We will not know about safety for many months.”

SOURCE: Bangkok Post | CNN

 

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1 Comment

1 Comment

  1. Avatar

    Edy F.

    Monday, August 31, 2020 at 6:22 pm

    Why not 4 doses ? Why do you believe these bullshits ? Look at the ingredients in vaccine and you will run far far away from this poison.. this is only propaganda for Big Pharm !

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Coronavirus (Covid-19)

PM Prayut Chan-o-cha seeks looser restrictions in ‘red’ zones

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Photo via Facebook/ PR Thai government

Covid-19 infections are still high, but PM Prayut Chan-o-cha says he wants restrictions to loosen up and businesses to reopen as soon as possible in provinces classified as “red” zones under tight control to combat Covid-19.

The prime minister says he has ordered governors of red zone provinces to look into easing disease control measures. Looking into each province’s Covid-19 situation and the restrictions’ impact on the local economy, governors are told to find a good balance that works well for both the economy and public health.

Spokesperson for the Centre for Covid-19 Situation Administration, Taweesilp Visanuyothin, says restrictions at restaurants in red zone provinces can be lifted if the situation improves.

PM Prayut Chan-o-cha seeks looser restrictions in 'red' zones | News by ThaigerPM Prayut Chan-o-cha seeks looser restrictions in 'red' zones | News by ThaigerSOURCE: Bangkok Post

 

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Thailand

American leaves hospital after being denied Covid treatment in same room as Thai wife

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Photo via The Pattaya News

An American man, who tested positive for Covid-19, is back in the hospital after fleeing when he was denied a shared room with this Thai wife-who was also undergoing Covid treatment. The 51 year old man left the northeastern Amnat Charoen province Chanuman hospital on May 9th after doctors declined to move his bed to that of his wife’s room. The man angrily went home without permission.

He was spotted walking on the road by local residents before being found by police at his home. The medical team convinced him to return to the hospital. But the incident has invoked stress among locals as they fear he could have spread the virus when he left the hospital. Thai social media was flooded with angry posts about the incident, with some calling for his arrest or deportation. In response, the Chanuman district chief has announced they will tighten security at the hospital to prevent any future incidents that are similar in nature.

The man’s name was not given, due to his Covid-19 status, and it has not been announced whether he will face any consequences after his actions.

Meanwhile, Thailand is reporting 1,630 new Covid-19 cases and 22 coronavirus-related deaths over the past 24 hours. There are now 29,376 active Covid-19 cases. Since the start of the pandemic last year, the CCSA has reported 85,005 Covid-19 cases and 421 Covid-related deaths.

Out of the 22 deaths, most of the patients had chronic illnesses. Many contracted the virus from family members or close friends.

Most of the new cases were detected in Bangkok, particularly in districts with crowded communities and markets. While cases in Bangkok continue to be high, CCSA spokesperson Natapanu Nopakun says the number of new cases in most other provinces in Thailand is decreasing.

Health officials are rolling out proactive case finding campaigns in several high-risk communities, testing 9,000 to 10,000 per day, Nopakun says, adding that officials are working to provide the appropriate treatment as quickly as possible.

Those who test positive for Covid-19 and are asymptomatic must stay at an official field hospital for 14 days and then self-isolate at home for another 14 days.

SOURCE: The Pattaya News

 

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Coronavirus (Covid-19)

Covid UPDATE: 1,919 new cases and 31 deaths, provincial totals

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Deputy spokesperson for the Ministry of Foreign Affairs Natapanu Nopakun / Photo courtesy of the Royal Thai Government

1,919 new Covid-19 cases and 31 coronavirus-related deaths were reported today in the Centre for Covid-19 Situation Administration’s daily briefing. Thailand now has 29,435 active cases. Since the start of the pandemic last year, the CCSA has reported a total of 86,924 infections and 452 Covid-related deaths.

At today’s CCSA briefing, Ministry of Foreign Affairs deputy spokesperson Natapanu Nopakun said that while the Covid-19 situation in Thailand may seem like it is stable, with cases decreasing or at zero in many provinces, the number of new infections reported each day is not declining.

“Infections are still concentrated in the hotspot which is Bangkok and the vicinity where several new cases were detected in active case finding.”

Out of the 1,919 new infections reported today, 885 were in Bangkok. Since April 1, more than 20,000 Covid-19 infections have been reported in the capital, first with clusters in the swanky Thong Lor nightlife district and now in the Khlong Toey slum.

Natapanu says that, fortunately, no new clusters were reported in Bangkok over the past day. He says a minor cluster was reported at a wet market in Nonthaburi, a suburb just outside Bangkok.

Out of the recent deaths, many had pre-existing conditions of high blood pressure and diabetes. Many contracted the virus from infected family members.

To prevent the emergence of the Covid-19 variant that was first detected in India, Natapanu says foreign nationals travelling from countries with the widespread transmission of the mutated strain are temporarily barred from entering Thailand. Thai embassies in Pakistan, Nepal and Bangladesh, where the Indian variant is spreading, have suspended the issuing of the required Certificate of Entry, or COE.

Covid UPDATE: 1,919 new cases and 31 deaths, provincial totals | News by Thaiger

Covid UPDATE: 1,919 new cases and 31 deaths, provincial totals | News by Thaiger

 

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