Connect with us

Coronavirus (Covid-19)

Singapore to begin human trial of potential Covid-19 prophylactic



PHOTO: Straits Times

A new drug, currently known as TY027, might be used to protect frontline healthcare workers against potential exposure to Covid-19, or travellers when they head to countries with high community transmission. Next week, 23 volunteers in Singapore will be involved in a clinical safety trial for the prophylactic antibody drug, which could be a viable treatment the disease that has already killed more than 400,000 around the globe.

The co-founder of Tychan, the biotech company behind the drug, told the media that if trials are successful, it could be used to render temporary protection against infection, as antibody drugs tend to be effective for about 2-3 weeks per dose. Using the drug to treat confirmed cases “could reduce a lot of problems we face right now,” such as the limited number of ventilators available at hospitals.

“One obvious thing is that a lot of the patients get sick for a very long time, and some of them even get very severe respiratory disease, so much so that you need oxygen ventilators to help them tie through this critical period, without which they would die. We hope this treatment will reduce the number of people who go into such a severe stage, and hopefully the number of people who die from Covid-19 can be kept to a minimum.”

But he noted that the eventual use of the drug, and who it will be administered to, will depend on the outcome of the Phase 1 clinical safety trial, which will take about 6 weeks. Singapore’s Health Sciences Authority granted approval for the trial on Monday. The trial, which will be conducted by SingHealth’s investigational medicine unit, will focus on evaluating the safety, tolerability and “pharmacokinetics,” the way the body reacts to the drug. If proven safe the drug will still have to undergo more tests before it can be used in real-life clinical settings, and that process could take months.

This is the first time an in-human trial for a Covid-19 treatment has been approved in Singapore. Presently, there is no proven antibody-based treatment for Covid-19, nor any licensed vaccine.

Tychan said in a statement that it produced the antibody on February 25, in partnership with Singpore’s Ministry of Defence, the Ministry of Health, the Economic Development Board and other government agencies as part of a whole-of-government collaborative effort. The company then identified it as the most promising among several antibodies that demonstrated 100% neutralisation against Covid-19. Since then, preclinical safety studies and other regulatory requirements, including a 3 week stability test, have been completed successfully.

SOURCE: SOURCE: Bangkok Post


Get more from The Thaiger

Join the conversation and have your say on Thailand news published on The Thaiger.

Thaiger Talk is our new Thaiger Community where you can join the discussion on everything happening in Thailand right now.

Please note that articles are not posted to the forum instantly and can take up to 20 min before being visible. Click for more information and the Thaiger Talk Guidelines.

Jack Burton is an American writer, broadcaster, linguist and journalist who has lived in Asia since 1987. A native of the state of Georgia, he attended the The University of Georgia's Henry Grady School of Journalism, which hands out journalism's prestigious Peabody Awards. His works have appeared in The China Post, The South China Morning Post, The International Herald Tribune and many magazines throughout Asia and the world. He is fluent in Mandarin and has appeared on television and radio for decades in Taiwan, Mainland China, Hong Kong and Macau.

Follow Thaiger by email:

Thailand7 hours ago

Thailand News Today | Thais more relaxed about Covid-19

Bangkok7 hours ago

‘Win’ motorbike taxi drivers protest against GrabBike in Bangkok, Thailand

World7 hours ago

China not cod-ing about its zero Covid policy as it tests fish

Travel7 hours ago

Affordable but stylish hotels in Koh Samui for your next holiday

Thailand7 hours ago

Female soldier seeks help after being abused by senator’s wife

Crime8 hours ago

2 fake monks make up to 40k baht per day scamming villagers in northern Thailand

Join the conversation on the Thaiger Talk forums today!
Crime9 hours ago

Man stabs wife’s secret lover to death in rice paddy in central Thailand

Thailand9 hours ago

Thailand movie legend Sombat Metanee has died, aged 85

Crime10 hours ago

Teen soldier murders cousin for allegedly raping his mother

Video10 hours ago

Thaiger Unfiltered

World11 hours ago

Monkeypox victims told to avoid animals after pet dog is infected

Thailand12 hours ago

Elephant rips mahout’s body in half in southern Thailand

Thailand12 hours ago

2 men on a motorcycle rob a gas station in Chon Buri

Thailand13 hours ago

PM Prayut suggests studying Buddhism to cope with rising electricity bills in Thailand

Thailand13 hours ago

Indian man arrested for smuggling 17 live animals out of Thailand

Thailand11 months ago

Morning Top Stories Thailand | Police to end protests, Human Trafficking | September 14

Thailand1 year ago

Thailand News Today | Thai Airways in rehab, All go for Songkran | March 4

Tourism1 year ago

Phuket’s nightlife. Yes, bars and clubs are still open | VIDEO

Phuket1 year ago

Thailand News Today | Covid passport talks, Thai Airways heads to court | March 2

Tourism1 year ago

Phuket Thai food treats you need to try | VIDEO

Thailand1 year ago

Thailand News Today | Bars, pubs and restaurants ‘sort of’ back to normal | Feb 23

Tourism1 year ago

In search of Cat & Dog Cafés in Phuket Town | VIDEO

Thailand2 years ago

Thailand News Today | Gambling crackdown, Seafood market to reopen, Vlogger challenge | Jan 21

Thailand2 years ago

Thailand News Today | Covid testing for visas, Business impact, Vaccine approval | January 19

Thailand2 years ago

Thailand News Today | Weekend Bangkok bombs, Thailand fires, Covid update | January 18

Thailand2 years ago

Thailand News Today | Stray car on runway, Indonesian quake, 300 baht tourist fee | January 15

Thailand2 years ago

Thailand News Today | Governor off respirator, sex-trafficking arrest, condo prices falling | January 14

Thailand2 years ago

Thailand News Today | Chinese vaccine, Thailand ‘drug hub’, Covid update | January 13

Thailand2 years ago

Thailand News Today | Bangkok may ease restrictions, Phuket bar curfew, Vaccine roll out | January 12

Thailand2 years ago

Thailand News Today | Covid latest, Cockfights closed down, Bryde’s Whale beached | January 11